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KMID : 0381120180400121339
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Genes and Genomics
2018 Volume.40 No. 12 p.1339 ~ p.1349
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Identification of pathways and genes associated with cerebral palsy
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Zhu Qingwen
Ni Yufei
Wang Jing
Yin Honggang
Zhang Qin
Zhang Lingli
Bian Wenjun
Liang Bo
Kong Lingyin
Xuan Liming
Lu Naru
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Abstract
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Cerebral palsy (CP) is a non-progressive neurological disease, of which susceptibility is linked to genetic and environmental risk factors. More and more studies have shown that CP might be caused by multiple genetic factors, similar to other neurodevelopmental disorders. Due to the high genetic heterogeneity of CP, we focused on investigating related molecular pathways. Ten children with CP were collected for whole-exome sequencing by next-generation sequencing (NGS) technology. Customized processes were used to identify potential pathogenic pathways and variants. Three pathways (axon guidance, transmission across chemical synapses, protein?protein interactions at synapses) with twenty-three genes were identified to be highly correlated with CP. This study showed that the three pathways associated with CP might be the molecular mechanism of pathogenesis. These findings could provide useful clues for developing pathway-based pharmacotherapies. Further studies are required to confirm potential roles for these pathways in the pathogenesis of CP.
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KEYWORD
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Cerebral palsy, Whole-exome sequencing, Molecular pathways, Axon guidance
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